Physics at Virginia

"Design principles of biological and chemical intelligence"

Zhiyue Lu , University of North Carolina at Chapel Hill
[Host: Marija Vucelja]

Living systems respond to external stimuli by utilizing chemical reaction networks that function as cellular information processors. What can we learn from living systems as the design principle of intelligent active materials? One salient example of a biological intelligence is the single-cell circadian clock (i.e. the Kai-ABC oscillator in cyanobacteria). Such circadian clocks process external signal (sunlight intensity) and computes the time during the day/night. These microscopic computers are naturally challenged by two main sources of uncertainty the internal thermal fluctuations and the external noisy signal. To optimize its performance, we find that a clock must make a tradeoff between resisting internal thermal fluctuations and external signal noise. This noise tradeoff relation can be explained through the geometry of its energy landscape. I will also discuss the use of the energy landscape in designing intelligent responses into mechanochemical materials.



Condensed Matter Seminar
Thursday, February 27, 2020
3:30 PM
Physics Building, Room 204
Note special room.

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