Physics at Virginia

"Voxelated Bioprinting: Digital Assembly of Viscoelastic Bio-ink Particles"

Liheng Cai , University of Virginia
[Host: Bellave Shivaram]

Analogues of pixels to two-dimensional (2D) pictures, voxels –– in the form of small cubes or spheres –– are the basic units of three-dimensional (3D) objects. Digital assembly of bio-ink voxels may provide an approach to engineering heterogeneous yet tightly organized 3D tissue mimics. However, this approach requires precisely manipulating highly viscoelastic bio-ink voxels in 3D space, which represents a grand challenge in both soft matter science and biomanufacturing. In this talk, I will introduce a voxelated bioprinting technology that enables the Digital Assembly of Spherical bio-ink Particles (DASP). First, I will discuss the criteria for the on-demand generation, disposition, and assembly of viscoelastic bio-ink droplets in an aqueous environment without the help of large interfacial tension. Second, I will describe how to use DASP to create 3D structures consisting of interconnected yet distinguishable bio-ink particles. Finally, I will share our recent progress in applying DASP to encapsulate islets into multiscale porous scaffolds to treat type 1 diabetes. I will also discuss immediate applications and emerging challenges associated with voxelated bioprinting.

Condensed Matter Seminar
Thursday, April 11, 2024
3:30 PM
Gibson Hall, Room 211
Note special room.

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