BEGIN:VCALENDAR VERSION:2.0 PRODID:Data::ICal 0.22 BEGIN:VEVENT DESCRIPTION:Anatoly Kolomeisky\, Rice University\n\n
The motion of molecu les across channels and pores is critically important for understanding me chanisms of many biological\, chemical\, physical and industrial processes . Here we investigate the role of different types of interactions in the c hannel-facilitated molecular transport by analyzing exactly solvable discr ete-state stochastic models. According to this approach\, the channel tran sport is a non-equilibrium process that can be viewed as a set of coupled quasi-chemical transitions between discrete spatially separated states. It allows us to obtain a full dynamic description of the translocation via t he pore\, clarifying many aspects of these complex processes. We show that the strength and the spatial distribution of the molecule/channel interac tions can strongly modify the particle fluxes through the system. Our anal ysis indicates that the most optimal transport is achieved when the bindin g sites are near the entrance or near the exit of the pore\, depending on the sign of the interaction potentials. These observations allow us to exp lain current single-molecule experiments on the translocation of polypepti des through biological channels. We also suggest that the intermolecular i nteractions during the channel transport might significantly influence the overall translocation dynamics. Our explicit calculations show that the i ncrease in the flux can be observed for some optimal interaction strengths . But the flux can also be fully suppressed for some conditions. The relev ance of these results for biological systems is discussed. The physical-ch emical mechanisms of these phenomena are analyzed from the microscopic poi nt of view.
\n DTSTART:20160415T193000Z LOCATION:Physics Building\, Room 204 SUMMARY:How to Understand Molecular Transport through Channels: The Role of Interactions END:VEVENT END:VCALENDAR