BEGIN:VCALENDAR VERSION:2.0 PRODID:Data::ICal 0.22 BEGIN:VEVENT DESCRIPTION:Ariel Amir\, Harvard University\n\n
Understanding how cells c ontrol and coordinate the various ongoing \;cellular processes\, such as DNA replication\, growth and division is an \;outstanding fundament al problem in biology. Remarkably\, bacterial \;cells may divide faste r than their chromosomes replicate\, implying \;that cells maintain mu ltiple rounds of chromosome replication\, and \;that tight control ove r DNA replication must be in place. I will show \;how ideas from stati stical mechanics and mathematical modeling can \;serve as alternative "\;microscopes"\; into this problem. Our results \;suggest tha t both cell size and chromosome replication may be \;simultaneously re gulated by following a simple control mechanism\, in \;which\, effecti vely\, a constant volume is added between two DNA \;replication initia tion events. This model elucidates the \;experimentally observed corre lations between various events in the \;cell cycle\, and explains the exponential dependence of cell size on \;the growth rate\, as well as recent experiments in which cell \;morphology is perturbed.
\n\nhttp://amir.seas.harvard.edu/< /p>\n DTSTART:20170324T193000Z LOCATION:Physics Building\, Room 204 SUMMARY:Controlling cell size and DNA replication in bacteria - insights fr om mathematical modeling END:VEVENT END:VCALENDAR